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Like other aminoglycosides, the bactericidal activity of Tobramycin is taken up into sensitive bacterial cells by an active transport process. Within the cell Tobramycin bind to the 30s, and to some extent to the 50s subunits of the bacterial ribosome, inhibiting protein synthesis and generating errors in the transcription of the genetic code. The manner in which cell death is brought about is imperfectly understood, and other mechanisms may contribute, including effects on membrane permeability.
Tobrabac eye drops is indicated for the treatment of external infections of the eye and its adnexa caused by susceptible bacteria.
Dosage And Administration
In mild to moderate infection, instill 1 drop 4-6 times daily into the conjunctival sac(s). In severe cases of infection, instill 1 drop hourly until improvement is obtained, then reduce the dose gradually. Duration of treatment is 5-15 days. Children: Clinical studies have shown Tobramycin ophthalmic preparation to be safe and effective for use in children.
The most frequent adverse reactions to Tobramycin are localized ocular toxicity and hypersensitivity, including lid itching and swelling and conjunctival erythema. These reactions occur in less than 3% of patients treated.
In patients with known hypersensitivity to any component of the product. Partial cross-allergenicity to other aminoglycosides has been established.
Specific drug interaction studies on Tobramycin ophthalmic preparation have not been established.
As with other anti-infective, prolonged use may result in overgrowth of non-susceptible organisms, including fungi. If super-infection occurs, discontinue use and institute alternative therapy. Patients should be advised not to wear contact lenses if they have signs and symptoms of bacterial conjunctivitis.
Not known and not likely in ophthalmic preparation.
Store at room temperature, protect from light. It is desirable that the contents should not be used more than 4 weeks after first opening of the bottle.
Dropper bottle of 5 ml.