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Alarup
Rupatadine
Alarup

Alarup Tablet: Each tablet contains Rupatadine Fumarate INN equivalent to 10 mg Rupatadine.

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Pharmacology/Description

Rupatadine is a second generation, non-sedating, long-acting histamine antagonist with selective peripheral H1 receptor antagonist activity. It further blocks the receptors of the platelet-activating factor (PAF) according to in vitro and in vivo studies. Rupatadine possesses anti-allergic properties such as the inhibition of degranulation of mast cells induced by immunological and non-immunological stimuli, and inhibition of the release of cytokines, particularly of the TNF (Tumor Necrosis Fator) in human mast cells and monocytes.

Indication

Rupatadine is indicated for the symptomatic treatment of # Seasonal allergic rhinitis # Perennial allergic rhinitis # Chronic idiopathic urticaria

Dosage And Administration

Adults and adolescents (over 12 years of age) - The recommended dose is 10 mg (one tablet) once a day, with or without food. Elderly (above 65 years) - Rupatadine should be used with caution in elderly. No information is available that indicates the requirement of any dose adjustment for this group of patients.

Side Effects

The most common undesirable effects associated with Rupatadine use in controlled clinical studies were somnolence (9.5%), headache (6.9%) and fatigue (3.2%). Other common undesirable effects include dizziness, dry mouth and asthenia.

Contraindications

The use of Rupatadine is contraindicated in patients with hypersensitivity to rupatadine or to any of the excipients.

Drug Interactions

Use with caution when administered concomitantly with inhibitors of the isozyme CYP3A4 e.g. Ketoconazole or Erythromycin. Psychomotor performance can be impaired when taken with alcohol. As with other antihistamines, interactions with CNS depressants cannot be excluded. Asymptomatic CPK (Creatinine Phospho Kinase) increases have been uncommonly reported. The risk of interactions with statins, is unknown; therefore, Rupatadine should be used with caution when it is coadministered with statins.

Precautions

Administration of a dose of 10 mg daily of Rupatadine has not shown significant effects on the function of the central nervous system as seen in specific studies done for psychomotor function. Nevertheless, the patient should take precaution in driving or managing machines.

Over Dosage

An accidental consumption of very high dose should be treated symptomatically together with the necessary supportive measures.

Pharmaceutical Precautions

Store in a cool and dry place, protected from light. Keep out of reach of children.

Commercial Pack

Alarup Tablet: Each commercial box contains 3 X 10 tablets in blister pack.