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Limaryl
Glimepiride
Limaryl

LimarylTM 1 tablet: Each tablet contains 1 mg Glimepiride USP. LimarylTM 2 tablet: Each tablet contains 2 mg Glimepiride USP. LimarylTM 3 tablet: Each tablet contains 3 mg Glimepiride USP. LimarylTM 4 tablet: Each tablet contains 4 mg Glimepiride USP.

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Pharmacology/Description

LimarylTM(Glimepiride) is an oral blood-glucose-lowering drug of the sulfonylurea class. The primary mechanism of action of glimeperide is lowering of blood glucose level by stimulating the release of insulin from functioning pancreatic ß cells.

Indication

LimarylTM is indicated as an adjunct to diet to lower the blood glucose in patients with non-insulin-dependent diabetes mellitus (type 2 diabetes) whose hyperglycemia cannot be controlled by diet, physical exercise and weight reduction. LimarylTM is also indicated for use in combination with Insulin.

Dosage And Administration

Usual starting dose: The initial dose of Glimepiride is 1-2 mg tablet once daily, administered with breakfast or the first main meal. The maximum starting dose should not be more than 2 mg. Maintenance dose: The usual maintenance dose is 1 to 4 mg daily. The maximum recommended dose is 8 mg once daily. After reaching a dose of 2 mg, dosage increases should be made in increments of not more than 2 mg at 1-2 weeks interval based upon the patient's blood glucose response.

Side Effects

Hypoglycemia, temporary visual impairment, nausea, vomiting, diarrhea, abdominal pain, urticaria, fall in blood pressure.

Contraindications

Hypersensitivity to Glimepiride, other sulfonylureas, other sulfonamides or any excipient. Diabetes ketoacidosis, with or without coma, severe impairment of renal function, dialysis patients and severe hepatic dysfunction.

Drug Interactions

Potentiation of the blood-suger-lowering effect may occur with Insulin and other oral anti-diabetics, ACE inhibitors, Aminosalicylic acid, anabolic steroids and male sex hormones, Azapropazone, Chloramphenicol, Cyclophosphamide, Disopyramide, Fenfluramine, Fenyramidol, fibrates, Fluconazole, Fluoxetine, Guanethidine, MAO-inhibitors, Miconazole, Oxpentifylline (high dose parenteral), Oxyphenbutazone, Para-aminosalicylic acid, Phenylbutazone, Probenecid, quinolones, salicylates, sulfonamide antibiotics, Tetracyclines, Tritoqualine, Trofosfamide. Drugs which may attenuate the hypoglycemic action of Glimepiride include: Acetazolamide, barbiturates, calcium channel blockers, corticosteroids, Diazoxide, diuretics, Glucagon, Isoniazid, laxatives (protracted use), Nicotinic acid (high doses), Oestrogens, Phenothiazines, Phenytoin, Progestogens, Rifampicin, sympathomimetic agents, thyroid hormones. H2 receptor antagonists, beta-blockers, Clonidine and Reserpine may lead to either potentiation or weakening of the blood-glucose-lowering effect.

Precautions

Glimepiride should be used with caution if the patient have experienced hospitalization for diabetes, have kidney disease, liver disease, heart disease, or any allergies. During times of stress such as fever, infection, injury or surgery, it may be more difficult to control blood sugar. Use in children: The safety and efficacy of Glimepiride in children have not been established. Glimepiride is not recommended for use in this age group. Use in pregnancy: This medication should be used only when clearly needed during pregnancy. Use in lactation: It is unknown if this drug is excreted into breast milk. Other similar drugs are excreted into breast milk. Nursing mothers must either be changed over to insulin or cease breast feeding.

Over Dosage

Accidental or intentional overdose may cause severe and prolonged hypoglycemia which may be life-threatening. In case of overdosage with Glimepiride, a doctor must be notified immediately. At the first signs of hypoglycemia, the patient must immediately take sugar, preferably glucose, unless a doctor has already started care.

Pharmaceutical Precautions

Store in a cool dry place protected from light. Keep out of reach of children.

Commercial Pack

LimarylTM 1 tablet: Each box contains 3X10 tablets in Alu-Alu blister pack and each tablet contains 1 mg Glimepiride USP. LimarylTM 2 tablet: Each box contains 3X10 tablets in Alu-Alu blister pack and each tablet contains 2 mg Glimepiride USP. LimarylTM 3 tablet: Each box contains 3X10 tablets in Alu-Alu blister pack and each tablet contains 3 mg Glimepiride USP. LimarylTM 4 tablet: Each box contains 3X10 tablets in Alu-Alu blister pack and each tablet contains 4 mg Glimepiride USP.