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Flupentixol & Melitracen

Anzet® tablet: Each film coated tablet contains Flupentixol Hydrochloride BP equivalent to 0.5 mg Flupentixol & Melitracen Hydrochloride INN equivalent to 10 mg Melitracen.

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It consists of two well known and well proven compounds; Flupentixol is a neuroleptic with anxiolytic and antidepressant properties when given in small doses, and Melitracen is a bipolar thymoleptic with activating properties in low doses. In combination the compound renders a preparation with antidepressant, anxiolytic and activating properties and mutually neutralizes side effects.

Mechanism of Action
Flupentixol acts by blocking the Dopamine (a neurotransmitter) receptors in the brain cells. Excess amount of dopamine receptors normally act to modify behavior and over-stimulation resulting in psychotic illness. Flupentixol blocks these receptors to control psychotic illness. Thus it is neuroleptic with anxiolytic and antidepressant properties. Melitracen acts by decreasing reuptake of norepinephrine and serotonin at the synapse resulting in high concentration of these neurotransmitters at the post-synaptic end. Thus it is antidepressant.


Anxiety, depression, apathy, Psychogenic depression, Depressive neuroses, Masked depression, Psychosomatic affections accompanied by anxiety and apathy, Menopausal depressions, Dysphoria and depression in alcoholics and drug addicts.

Dosage And Administration

Adults: Usually 2 tablets daily; morning and noon. In severe cases the morning dose may be increased to 2 tablets. Elderly patients: 1 tablet in the morning. Maintenance dose: Usually 1 tablet in the morning. In case of insomnia or severe restlessness additional treatment with a sedative in the acute phase is recommended.

Children: Not recommended.

Side Effects

In the recommended doses side effects are rare. These could be transient restlessness and insomnia.


The immediate recovery phase after myocardial infarction. Defects in bundle-branch conduction, untreated narrow angle glaucoma, acute alcohol, barbiturate and opiate intoxication. Flupentixol-Melitracen should not be given to patients who have received a MAO-inhibitor within two weeks. Not recommended for excitable or overactive patient since its activating effect may lead to exaggeration of these characteristics.

Drug Interactions

Flupentixol and Melitracen may enhance the response to alcohol, barbiturates and other CNS depressants. Simultaneous administration of MAO-inhibitors may cause hypertensive crises. Neuroleptics and thymoleptics reduce the antihypertensive effect of guanethidine and similar acting compounds and thymoleptics enhance the effects of adrenaline and noradrenaline.


If previously the patient has been treated with tranquilizers with sedative effects these should be withdrawn gradually. Use in Pregnancy and Lactation: Flupentixol - Melitracen should preferably not be given during pregnancy and lactation.

Over Dosage

Symptoms: In cases of overdosage the symptoms of intoxication by Melitracen, especially of anticholinergic nature, dominate. More rarely extrapyramidal symptoms due to Flupentixol occur. Treatment: It should be symptomatic and supportive. Gastric lavage should be carried out as soon as possible and activated charcoal may be administered. Measures aimed at supporting the respiratory and cardiovascular
systems should be instituted. Epinephrine (adrenaline) must not be used for such patients. Convulsions may be treated with Diazepam and extrapyramidal symptoms with biperiden.

Pharmaceutical Precautions

Store in a cool dry place protected from light. Keep out of reach of children.

Commercial Pack

Anzet® tablet: Each box contains 10X10 tablets in blister pack.