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Losatan HZ
Losartan & Hydrochlorothiazide
Losatan HZ

Losatan® HZ tablet: Each tablet contains 50 mg Losartan Potassium USP and 12.5 mg Hydrochlorothiazide BP.

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Pharmacology/Description

Losartan Potassium is an angiotensin II receptor (type I) blocker. Hydrochlorothiazide is a thiazide diuretic. The diuretic action of Hydrochlorothiazide reduces plasma volume.

Indication

Losartan Potassium and Hydrochlorothiazide combination is indicated for the treatment of hypertension.

Dosage And Administration

A patient whose blood pressure is not adequately controlled with Losartan monotherapy or Hydrochlorothiazide alone, may be switched to Losartan® HZ once daily. If blood pressure remains uncontrolled after about 3 weeks of therapy, the dose may be increased to two tablets of Losartan® HZ once daily.

Side Effects

In general, treatment with this combination is well tolerated. For the most part, adverse experiences have been mild and transient in nature and have not required discontinuation of therapy. The adverse experiences such as abdominal pain, dizziness, cough, rash etc. have been reported with this combination in very few numbers of patients.

Contraindications

Patients who are hypersensitive to any component of this product.

Drug Interactions

No drug interactions of clinical significance have been identified for Losartan. Hydrochlorothiazide may affect alcohol, barbiturates, narcotics and corticosteroids.

Precautions

When pregnancy is detected, Losatan® HZ should be discontinued as soon as possible.

Over Dosage

Limited data are available in regard to over dosage of Losartan Potassium in humans. The most likely manifestations of over dosage would be hypotension, tachycardia, and bradycardia. If symptomatic hypotension occurs, supportive treatment should be instituted. Neither Losartan nor its active metabolite can be removed by hemodialysis. The most common signs and symptoms observed for Hydrochlorothiazide are those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis.

Pharmaceutical Precautions

Store in cool dry place protected from light. Keep out of reach of children.

Commercial Pack

Losatan® HZ tablet: Each box contains 3 X 10 tablets in blister pack