Indication

1. Prophylaxis: The prevention of postoperative infections caused by anaerobic bacteria, especially those associated with colonic, gastrointestinal and gynecological surgery. 2. Treatment of the following anaerobic infections.: Intraperitoneal infections: peritonitis, abscess; gynecological infections: endometritis, endomyometritis, tuboovarian abscess, bacterial septicaemia, post operative wound infections, skin and soft tissue infections, upper and lower respiratory tract infections: pneumonia, empyema, lung abscess. 3. Nonspecific vaginitis 4. Acute ulcerative gingivitis 5. Urogenital trichomoniasis in both male and female patients. 6. Mixed trichomonal and candidal infections. 7. Giardiasis 8. Intestinal amoebiasis 9. Amoebic involvement of the liver.


Dosage & Administration

Prevention of Postoperative Infections Adult: A single oral dose of 2g approximately 12 hours before surgery. Children less than 12 years: Data are not available to allow dosage recommendations for children below the age of 12 years in the prophylaxis of anaerobic infections. 1. Trichomoniasis: a single 2 g oral dose taken with food. Treat sexual partners with the same dose and at the same time 2. Giardiasis: Adults: a single 2 g dose taken with food. Pediatric patients older than three years of age: a single dose of 50 mg/kg (up to 2 g) with food 3. Amebiasis, Intestinal: Adults: 2 g per day for 3 days with food. Pediatric patients older than three years of age: 50 mg/kg/day (up to 2 g per day) for 3 days with food 4. Amebic liver abscess: Adults: 2 g per day for 3-5 days with food. Pediatric patients older than three years of age: 50 mg/kg/day (up to 2 g per day) for 3-5 days with food 5. Bacterial vaginosis: Non-pregnant, adult women: 2 g once daily for 2 days taken with food, or 1 g once daily for 5 days taken with food.


Precautions

Compounds of similar chemical structure have produced various neurological disturbances such as dizziness, vertigo, uncoordination, and ataxia. If, during therapy with tinidazole, abnormal neurological signs develop, therapy should be discontinued. Use in Pregnancy & Lactation: Tinidazole is contraindicated during the first trimester of pregnancy. While there is no evidence that tinidazole is harmful during the late stages of pregnancy, its use during the last two trimesters requires that the potential benefits outweigh the possible risk to mother and foetus. Tinidazole is excreted in breast milk in concentrations similar to those seen in serum. Tinidazole can be detected in breast milk for up to 72 hours following administration. Interruption of breast-feeding is recommended during tinidazole therapy and for 3 days following the last dose.


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