- Induction of general anesthesia
- Anesthesia of short duration
- Reduction of raised intracranial pressure if ventilation controlled
- Status epilepticus
Dosage & Administration
Induction of general anesthesia: By intravenous injection usually as a 2.5%
(25 mg/ml) solution, in fit premedicated adults, initially 100-150 mg over
10-15 seconds, followed by further quantity if necessary according to
response after 30-60 seconds up to 4 mg/kg (max. 500 mg).
Child: Induction 2-7 mg/kg.
Raised intracranial pressure: By intravenous injection 1.5-3 mg/kg, repeated
Status epilepticus: (Only if other measures fail) by intravenous injection as a
2.5% (25 mg/kg) solution, 75-125 mg as a single dose.
- Observe aseptic precautions at all times in preparation and handling of Thiopental Sodium solutions for Injection.
- If used in conditions involving relative contraindications, reduce dosage and administer slowly.
- Care should be taken in administering the drug to patients with advanced cardiac disease, increased intracranial pressure, ophthalmoplegia plus, asthma, myasthenia gravis and endocrine insufficiency (pituitary, thyroid, adrenal, pancreas).
Use in Pregnancy & Lactation
Pregnancy Category C. Animal reproduction studies have not been conducted with Thiopental. It is also not known whether Thiopental can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Thiopental should be given to a pregnant woman only if clearly needed. Thiopental sodium readily crosses the placental barrier and small amounts may appear in the milk of nursing mothers following administration of large doses.