Indication

MetonidTM is indicated in the prophylaxis and treatment of infections in which anaerobic bacteria have been identified or are suspected to be the causes. It is particularly suited for patients who can not retain oral medication and for patients in whom desired serum concentration have to be attained rapidly and reliably. MetonidTM is indicated:
1. In the prevention of post operative infections due to anaerobic bacteria
2. In the treatment of -
a. Intra abdominal infections- appendicitis, cholecystitis, peritonitis, liver abscess and post operative wound infections
b. Gynaecological and obstetrical infections- puerperal sepsis, pelvic cellulitis, pelvic peritonitis
c. Respiratory infections- necrotizing pneumonia, empyema and lung abscess
d. Central Nervous System infections- meningitis, brain abscess
e. Miscellaneous infections-septicaemia, bacteremia, osteomyelitis, gas gangrene


Dosage & Administration

MetonidTM may be diluted with appropriate volumes of normal saline, dextrose-saline, dextrose 5% w/v or potassium chloride (20 and 40 mmol) infusions.


For Prophylaxis & treatment of anaerobic infections

Adults

Children

Dose

 100ml (500mg) immediately before,

during or after operation,

1.5 ml (7.5 mg) per

kg   body   weight

every 8 hours

Duration

Treatment for 7 days should be satisfactory for bacteriological assessments, the physician may decide to prolong the treatment

Infusion rate

Metonid should be infused at an approximate

rate of 5 ml/minute



Precautions

Regular clinical and laboratory monitoring are advised if administration of MetonidTM for more than 10 days is considered to be necessary. Metronidazole should be administered with caution to patients with hepatic encephalopathy. Caution is advised in patients with active disease of the central nervous system other than brain abscess. Infusion of fluid should be immediately discontinued if rigor arises for any reason during the process. Do not use if the solution is cloudy, contains particles or after expiry date. Use in Pregnancy & Lactation: There is inadequate evidence of the safety of metronidazole in pregnancy. Metronidazole is excreted in milk and no adverse effects in the newborn have been reported. Metonid should therefore be given during pregnancy or during lactation only when the physicians consider it essential.


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