1.Stimulation of gut motility in a) non-ulcer dyspepsia b) esophageal reflux, reflux esophagitis and gastritis c) diabetic gastroparesis d) functional dyspepsia e) speeding barium transit in follow through radiological studies.
2. Prevention and symptomatic relief of acute nausea and vomiting from any cause including cytotoxic therapy, radiotherapy and anti-parkinsonism therapy. 3. In the treatment of migraine.
Dosage & Administration
The recommended oral dose for adults: 10-20 mg (1-2 tablet or 10-20 ml suspension) 3-4 times daily, children: 0.2-0.4 mg/kg or 2-4 ml suspension /10 kg, 3-4 times daily. Note: Domperidone should be taken 15-30 minutes
before a meal. For acute nausea and vomiting, maximum period of time is 12 weeks.
Domperidone should be used with absolute caution in case of children because there may be an increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood brain barrier.
Use in pregnancy: The safety of Domperidone has not been proven and it is therefore not recommended during pregnancy. Animal studies have not demonstrated teratogenic effects on the fetus.
Use in lactation: Domperidone may precipitate galactorrhoea and improve post-natal lactation. It is secreted in breast milk but on very small quantities, insufficient to be considered harmful.