Doxofyl (Doxofylline) is used to treat Asthma, COPD and Bronchospasm.
Dosage & Administration
Adults: 400 mg once daily in the evening. On the basis of clinical response, the dose may be increased to 2-3 tablets daily (not more than 1200 mg/daily)
Elderly Patients: 200 mg two or three times daily.
Children (>6 years of age): 6 mg/kg body weight twice daily, i.e. if body weight is 15 kg, 90 mg twice daily.
The half-life of Xanthine derivatives is influenced by a number of known variables. It may be prolonged in patients with liver disease, in patients with congestive heart failure and in those patients taking certain other drugs like Erythromycin, Troleandomycin, Lincomycin, Allopurinol, Cimetidine, Propanolol and Anti-flu vaccine. In these cases, a lower dose of Doxofylline may be needed. Phenytoin , other anticonvulsants and smoking may cause an increase in clearance with a shorter mean half-life. In these cases higher doses of Doxofylline may be needed.
Use in Pregnancy & Lactation
Animal reproduction studies indicate that, Doxofylline does not cause fetal harm when administered to pregnant animals or can not affect reproduction capacity. However, since there is limited experience in human during pregnancy, xanthines should be given to pregnant women only if clearly needed. Doxofylline is contraindicated in nursing mothers.