Prostanor is indicated for the treatment of the signs and symptoms of Benign Prostatic Hyperplasia (BPH).
Dosage & Administration
Prostanor 4 mg: Prostanor 4 mg capsules taken orally once daily with a meal for those with moderate renal impairment [Creatinine Clearance (CCr) 30-50 ml/min].
Prostanor 8 mg: Prostanor 8 mg capsules taken orally once daily with a meal.
Dose adjustment for Hepatic and Renal Impaired patients
Renal Impairment: Silodosin should be reduced to 4 mg per day in patients with moderate Renal Impairment. Silodosin is contraindicated in patients with severe Renal Impairment (CCr < 30 ml/min).
Hepatic Impairment: No dosing adjustment is required in patients with mild or moderate Hepatic Impairment. Silodosin is contraindicated in patients with severe Hepatic Impairment (Child-Pugh score > 10).
Postural hypotension with or without symptoms (e.g. dizziness) may develop when beginning Silodosin treatment. Silodosin should not be used in combination with other alpha-blockers. Inform patients planning cataract surgery to notify their ophthalmologist that they are taking Silodosin because of the possibility of Intraoperative Floppy Iris Syndrome (IFIS)
Use in special group
In Pregnancy: Silodosin is not indicated for use in women.
Usage in Pediatric patient: Silodosin is not indicated for use in pediatric patients.