Treatment of the following infections caused by susceptible strains of the designated microorganisms:

Middle Ear: Otitis media caused by S. pneumoniae, H. influenzae (betalactamase positive and negative strains), B. catarrhalis (beta-lactamase positive and negative strains) and S. pyogenes. Paranasal Sinuses: Sinusitis caused by S. pneumoniae, H. influenzae (beta-lactamase positive and negative strains), and B. catarrhalis (beta-lactamase positive and negative strains). Urinary Tract: Acute uncomplicated cystitis and urethritis caused by E. coli, P. mirabilis, and Klebsiella species. Upper Respiratory Tract: Pharyngitis and tonsillitis caused by S. pyogenes. Lower Respiratory Tract: Acute bronchitis caused by S. pneumoniae, B. catarrhalis (beta-lactamase positive and negative strains) and H. influenzae (beta-lactamase positive and negative strains). Uncomplicated Gonorrhea: Uncomplicated gonorrhea (cervical/urethral and rectal) caused by N. gonorrhoeae, including penicillinase (beta-lactamase-positive) and nonpenicillinase (beta-lactamase-negative) producing strains.

Dosage & Administration

Adult: 1 or 2 capsules (200-400 mg) as once or in 2 divided doses daily for 7-14
days, according to the severity of the infection.
Children above 6 months: 8 mg per kg body weight as a single dose or in two
divided doses for 7-14 days according to the severity of the infection or as
6 months-1 year: 75 mg/day
1-4 years: 100 mg/day
5-10 years: 200 mg/day
11-12 years: 300 mg/day
Above 12 years: Adult dose may be administered.


Efficacy and safety in infants aged less than six months have not been established.


Direction for Reconstitution
Zemicef TM 30 ml, 40 ml & 50 ml and ZemicefTMDS 50 ml suspension: One bottle contains the powder; another bottle contains the diluent. Shake the bottle to loosen the powder. Now pour the diluent completely into the bottle of powder. For ease of preparation, pour the diluent in two portions. Do not add extra water to the suspension. Close the bottle tightly & shake the bottle gently until the powder is dissolved properly. Now the suspension is ready for use. Shake the bottle well before each use.


Cefixime should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis. Dosage adjustment is only necessary in severe renal failure (creatinine clearance < 20 ml/min). Use in pregnancy and lactation: No data is available, so it is probably the best to avoid using the drug during pregnancy and by the nursing mothers.

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