Natamycin ophthalmic suspension is indicated for the treatment of fungal blepharitis, conjunctivitis and keratitis caused by susceptible organisms including Fusarium solani keratitis.

Dosage & Administration

Shake well before use
The preferred initial dosage in fungal keratitis is one drop of Natamycin ophthalmic suspension instilled in the conjunctival sac at hourly or two-hourly intervals. The frequency of application can usually be reduced to one drop 6 to 8 times daily after the first 3 to 4 days. Therapy should generally be continued for 14 to 21 days or until there is resolution of active fungal keratitis. Less frequent initial dosage (4 to 6 drops daily application) may be sufficient in fungal blepharitis and conjunctivitis.


Do not touch dropper tip to any surface, as this may contaminate the suspension. Patient should be advised not to wear contact lenses if they have signs and symptoms of fungal blepharitis, conjunctivitis and keratitis. Failure of improvement of keratitis following 7-10 days of administration of the drug suggests that the infection may be caused by a microorganism not susceptible to Natamycin. Continuation of therapy should be based on clinical re-evaluation and additional laboratory studies. Adherence of the suspension to areas of epithelial ulceration or retention of the suspension in the fornices occurs regularly.


Use in Pregnancy and Lactation
Pregnancy category C.
Animal reproduction studies have not been conducted with Natamycin. It is also not known whether Natamycin can ca use fetal harm when administered to the pregnant women or can affect reproduction capacity. Natamycin ophthalmic suspension should be given to a pregnant woman only if clearly needed.
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Natamycin is administered to a nursing woman.

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